Sep 14, 2021 Uncategorized

Immunology Worksheet assignment at an affordable cost

Description

Please answer the following questions, Please note that the multiple choice questions may require you to circle more than one answer. All questions are worth 2 points each. Answers to the short answer questions should provide the specific information requested. If required, proteins should be named, and their function also described.

1. Naïve B cells get activated in:

a. the bone marrow

b. the thymus

c. the spleen

d. lymph nodes

e. MALTS

2. Naïve TH cells get activated in:

a. the bone marrow

b. the thymus

c. the spleen

d. lymph nodes

e. MALTS

3. Secondary lymphoid tissue:

a. is where naïve B cells develop from the lymphocyte precursor

b. is where neutrophils are stored

c. contains loosely organized clumps of B cells called primary follicles

d. is found only in your intestines

e. is the site where activated T cells and B cells interact with each other

4. The cortex of a lymph node:

a. is where T cells migrate after leaving blood vessels through HEV

b. contains fibroblast reticular cells (FRC)

c. contains follicular dendritic cells (FDC)

d. contains primary follicles

e. is where B cells migrate after leaving blood vessels through HEV

5. The paracortex of a lymph node:

a. is where T cells migrate after leaving blood vessels through HEV

b. contains fibroblast reticular cells (FRC)

c. contains follicular dendritic cells (FDC)

d. contains primary follicles

e. is where B cells migrate after leaving blood vessels through HEV

6. Antigens:

a. are the same as epitopes

b. must be living

c. are the same as pathogens

d. contain epitopes

e. are substances that bind to antibodies

7. Epitopes:

a. are exactly the same thing as antigens

b. are composed of short peptide regions

c. are another word for pathogen

d. bind directly to a lymphocyte receptor

e. are never found on human proteins

8. The HLA locus in humans:

a. contains the genes that encode MHC I-alpha chain

b. contains the genes that encode MHC II-alpha and -beta chains

c. contains genes that encode some complement proteins

d. contains immunoglobulin genes

e. is inherited as a single genetic unit

9. A loss of function mutation in b2 microglobulin (resulting in no b2 microglobulin being made in the cell) will cause:

a. loss of neutrophils

b. increase in NK cells

c. inability to express MCH I on the surface of cells

d. inability to express MHC II on the surface of cells

e. inability to present endogenous antigens

10. Polymorphism in MHC proteins:

a. is restricted to MHC I proteins, not MHC II

b. increases one’s ability to bind a wide variety of antigen fragments

c. is the same as polygeny

d. is one reason that transplanted tissue can be rejected by the host

e. benefits a population, as well as an individual

11. If an antigen is made inside a cell, using the cells ribosomes:

a. it is digested in a lysosome/late endosome

b. it is digested by the ubiquitin-proteosome system

c. it is presented on MHC I to T(CD8+) cells

d. it is presented on MHC I to T(CD4+) cells

e. it is presented on MHC II to T(CD4+) cells

12. CD4:

a. is required for signal 1 in TH cells

b. is required for signal 1 in TC cells

c. binds to MHC I

d. binds to MHC II

e. is on the surface of B cells

13. Signal 1 for B cell activation:

a. comes from TH cells

b. comes from macrophages

c. comes from dendritic cells

d. comes from antigen binding to mIg and crosslinking BCRs

e. requires Ig-a and Ig-b

14. Signal 2 for TH cell activation requires (direct involvement in the process):

a. Fc (stem) region of membrane immunoglobulins

b. B7

c. CD28

d. CD8

e. Ig-a

15. B7 is a protein:

a. on the surface of neutrophils

b. on the surface of professional antigen presenting cells

c. on the surface of TH cells

d. that is required to activate Tcells

e. that binds to CD4

16. The class (IgA, IgG, etc) of secreted antibodies:

a. is determined by Signal 2 in B cell activation

b. all have slightly different stem regions

c. is what helps antibodies bind to antigens

d. is what determines the effector function of an antibody

e. is specified by cytokines for signal 3 secreted by TH cells during B cell activation

17. Which of the following statements are correct for TREG cells:

a. They generally have CD4+ on their surface

b. They express the transcription factor FoxP3

c. They can convert naïve TH cells into TREG cells

d. There are more of them in people who eat lots of chocolate cake

e. They are can develop in response to signals from the gut microbiome

18. CD3:

a. binds directly to MHC I

b. is on TH cells

c. is on Tc cells

d. is on B cells

e. is part of the T Cell Receptor Complex

19. CD40:

a. is part of signal 2 in B cell activation

b. is on TH cells

c. is on B cells

d. is on TC cells

e. can help activate Tc cells

20. IL-2:

a. is produced by B cells

b. is a growth factor

c. is produced by Tcells as a result of signal 2 in TH cell activation

d. is a survival signal

e. is not needed to activate TC cells

21. Which of the following are effector TH cells?

a. TH2

b. TH15

c. TH1

d. TH17

e. CTL

22. Which of the following Immunoglobulin classes are secreted by plasma cells?

a. IgB

b. IgA

c. IgG

d. IgM

e. IgD

23. What types of cells express MHC I on their surfaces? What types of cells express MHC II on their surfaces?

24. Why must antigen presenting cells express B7 when activating Tcells? What happens if they do not have B7? Be specific.

25. Where does Signal 3 for TH cell activation come from? What determines which signal 3 cytokines are expressed?

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